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Waiting for Mutations: Why Darwinism Won’t Work

Ann Gauger

Homo_georgicus.jpg

Many scientists now recognize the insufficiency of the classic Darwinian story to account for the appearance of new features or innovations in the history of life. They focus on other theories to account for remarkable differences between genomes, the appearance of novel body plans, and genuine innovations like the bat’s wing, the mammalian placenta, the vertebrate eye, or insect flight, for example. They realize that the traditional story of population genetics (changes in allele frequencies in populations due to mutation, selection, and drift) cannot account for “the arrival of the fittest” and not just the “survival of the fittest.” (Hugo DeVries, 1904).

One of the reasons many scientists acknowledge the insufficiency of Darwinism is because they know the accounting won’t work. The mutation rate, the generation times, the strength of selection versus genetic drift, the population sizes, and the time available don’t match up.

For example, supposedly humans last shared common ancestry with chimps about six million years ago. Since that time, we have accumulated significant differences with chimps — genetic, anatomical, physiological, behavioral, and intellectual differences, among others. The genetic differences between humans and chimps are much more than the (shrinking) 1.2 percent difference in base pairs that is so often quoted in the media. Add small insertions and deletions and the differences climb to about 3-5 percent, depending on whose estimate is used. Add another 2.7 percent for large scale duplications or deletions, another .4% percent for new repetitive genetic elements, .3% for the Y chromosome differences and some unknown number for rearrangements of the DNA, or new genes, we have more than 7.7 percent of our genome with unique features not present in chimps.

There is only so much time for these differences to have accumulated. Mutations arise and are propagated from generation to generation, so the number of generations limits how many mutations can accumulate. The estimated mutation rate is about 10-8 per base pairs per generation, and we have an average generation time of somewhere between 10 and 25 years. Our estimated breeding population size six million years ago is thought to have been about 10,000 (these are all rough estimates based on numbers currently in use — see the papers cited below). Based on these numbers, one can estimate how many years it would take to acquire all those mutations, assuming every mutation that occurred was saved, and stored up.

But there’s a difficulty — it’s called genetic drift. In small populations, like the 10,000 estimate above, mutations are likely to be lost and have to reoccur many times before they actually stick. Just because of random effects (failure to reproduce due to accidental death, infertility, not finding a mate, or the death of all one’s progeny), a particular neutral mutation may have to arise many times before it becomes established in the population, and then many more years before it finally becomes fixed (that is, before it takes over the population and replaces all other versions).

How long before a single, new mutation appears and becomes fixed? An estimate from a recent paper using numerical simulations is 1.5 million years. That is within the range of possibility. But what if two specific mutations are needed to effect a beneficial change? Their estimate is 84 million years. Other scientists have done this calculation using analytical methods, but their numbers are even worse. One report calculates 6 million years for one specific base change in an eight base target typical of the size of a DNA binding site to fix, and 100 million years to get two specific mutations. (That work was later amended to 216 million years.) Extrapolating from other published data merely confirms the problem.

Another paper came up with much shorter time frames by assuming that any 5 to 10 base pair binding site could arise anywhere within 1 Kb of any promoter within the genome.

Yet in all likelihood many more than two binding sites would be required to change anything significant, and those binding sites must be appropriate in location and in sequence to accomplish the necessary changes. They must work together in order for a specific adaptive change to happen.

Genes operate in networks, and to shift a gene regulatory network would require many mutations, and not just random ones. Remember there are anatomical physiological, behavioral, and intellectual differences to explain, multiple traits each requiring multiple coordinated mutations. Unless one invokes luck on a large scale, those traits would not have come to be.

I’m not betting on luck.

Update: It has come to my attention since this piece was first published that my numbers for new repetitive elements were wrong. I have amended my estimate using figures taken from the Chimp Genome Project, and also used more conservative estimates for small indels, in order to be as careful as possible.

Image: Homo georgicus, reconstruction, photo by 120 (Own work (photograph), model by Elisabeth Daynes) [CC BY-SA 3.0], via Wikimedia Commons.

Ann Gauger

Senior Fellow, Center for Science and Culture
Dr. Ann Gauger is Director of Science Communication and a Senior Fellow at the Discovery Institute Center for Science and Culture, and Senior Research Scientist at the Biologic Institute in Seattle, Washington. She received her Bachelor's degree from MIT and her Ph.D. from the University of Washington Department of Zoology. She held a postdoctoral fellowship at Harvard University, where her work was on the molecular motor kinesin.

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