There seems to be an idea floating about among some biologists that it is easy to recombine protein domains or swap bits of protein structure to generate new function.
How does a neo-Darwinian process evolve an enzyme like carbamoyl phosphate synthetase?
The extraordinary specified complexity embedded in their sequences is too much to be the result of random processes.
All simians and primates except humans are infected with certain groups of lineage-specific viruses. How did we lose these viruses if we are descended from primate ancestors who had them?
Even if it takes only 30 or 40 specific trait changes to move from primate to human, and hundred of mutations, the time required would be astronomical.