Alas, Coyne’s review of Darwin Devolves has too little intellectual content to sustain any real engagement.
Computer methods of analyzing mutations are widely used because they are generally accurate. They do not suddenly lose their accuracy when I cite them.
Richard Lenski has spent decades overseeing the most extensive, most acclaimed laboratory evolution experiment conducted to date.
A very common way to try to discredit an argument is to exaggerate it, ignore distinctions an author makes, and/or change carefully qualified claims into bizarre absolutes.
In a few days I will offer a detailed rebuttal. But here is the overwhelmingly important point to notice right up front.