Lang and Rice cite a number of articles to show that loss-of-function mutations are just a small minority of those found in studies of organisms.
Their review pretty much completely misses the mark. Nonetheless, it is a good illustration of how sincere-yet-perplexed professional evolutionary biologists view the data.
Professor Lenski’s contrasting of the frequency versus importance of evolutionary changes is misconceived and his illustrations are inapt.
Alas, Coyne’s review of Darwin Devolves has too little intellectual content to sustain any real engagement.
Computer methods of analyzing mutations are widely used because they are generally accurate. They do not suddenly lose their accuracy when I cite them.