Dennis Venema’s arguments about Michael Yarus’s work were already addressed in detail by Meyer and Nelson in a technical paper.
Douglas Axe is a protein scientist who has published work on the rarity of new protein folds by doing research on beta-lactamase enzymes.
A bottleneck of two, or a first pair at our origin older than 500,000 years, is possible.
None of these discussions are relevant to whether Adam and Eve existed, but they are relevant to intelligent design.
Both evolutionists and Darwin-skeptics believe that all living humans trace back to a common female ancestor, and a common male ancestor.