Darwinist mathematician Jason Rosenhouse uses the analogy of a coin toss to defend the Darwinian explanation.
There are some biologists, such as Richard Dawkins, who still pin their faith in ideas which have resulted only in blankly negative experimental results.
Replication or transcription of DNA stresses the macromolecule, resulting in supercoiling. Topoisomerase II relieves the stress.
There’s a problem that biologists have long pondered — how do proteins find other proteins within the cell that they are supposed to interact with?
Science provides a clear expectation of what natural processes produce, and what we observe in the biopolymers of life is dramatically unexpected.