Thank Goodness the NCSE Is Wrong: Fitness Costs Are Important to Evolutionary Microbiology

The evolution of antibiotic resistance is typically the result of small changes allowing for survival in a microbe or other organism under special circumstances where the organism faces extremely strong selection pressure due to the presence of some antibiotic drug. In other cases, it is the result of the transfer of pre-existing antibiotic resistance genes from one microbe to another, and the selection of such microbes in an environment containing antibiotics. Even in the first example, evolution does not produce a truly new function. In fact the change produced often makes the microbe less fit when the antibiotic is removed–it reproduces slower than it did before it was changed. This effect is widely recognized, and is called the fitness cost Read More ›