Darwinist Jerry Coyne misunderstands design science. Intelligent design is two scientific inferences.
In effect, protein engineers are using the power of random change plus intelligent design to see what if anything will improve function.
The nucleus is a beehive of activity, where information is not just stored but processed, protected, transcribed, and duplicated by highly complex machines.
Lents studies rotting corpses and household plants. He might not know much about (living) human physiology.
Any appeal to accidental processes to accomplish an unbelievable coincidence is really just an appeal to unbelievable coincidence.