Materialists argue that dualism of mind and brain is not possible because of causal closure — by which they mean that all physical effects have physical causes.
Imagine a chain hanging from the sky supporting a weight suspended in the air. Each link in the chain is a cause for the continued suspension of the links.
The pretense not to know things is at the root of Darwinist/atheist/materialist ideology.
A materialist view of reality leaves out much of reality (love, reason, mercy, truth, etc.) so skittish materialists often call themselves “physicalists.”
What is inevitable here is not the mathematical beauty of physical law, but the circumlocutions scientists use to evade design in nature.