There are some biologists, such as Richard Dawkins, who still pin their faith in ideas which have resulted only in blankly negative experimental results.
Replication or transcription of DNA stresses the macromolecule, resulting in supercoiling. Topoisomerase II relieves the stress.
Scientists have been trying for decades to get monomers to link up into biopolymers under “prebiotically plausible conditions.”
Remember when fossil hunters found Marble Canyon, a fossil bed in Canada that surpassed the Burgess Shale in extent and species richness?
A paper illustrates the action of DNA loop extrusion processes, which serve multiple functions to maintain the genome, with an interesting graphic: gears.