We still are not close to designing any self-replicating machine. That is still pure science fiction.
The core difficulty for some scientists who read Michael Behe’s book is also the key idea at its heart.
The greatest engine of atheism in modern times — Darwin’s theory — is nothing more than a bastardization of the strongest philosophical argument for God’s existence.
A bottleneck of two, or a first pair at our origin older than 500,000 years, is possible.
Most studies simply infer or invent some story about the evolution of a gene without any experimental tests.