It was interesting to see fellow University of Chicago biologist Jerry Coyne casually shoehorn Thornton into a Washington Post review of Darwin Devolves.
Professor Lenski revisits a series of experiments on the bacteriophage lambda begun by his lab around 2012.
Lenski agrees that the beneficial mutations seen in his Long Term Evolution Experiment are overwhelmingly degradative or loss-of-function ones.
Professor Lenski’s contrasting of the frequency versus importance of evolutionary changes is misconceived and his illustrations are inapt.
Computer methods of analyzing mutations are widely used because they are generally accurate. They do not suddenly lose their accuracy when I cite them.