Naturally occurring self-organization is fundamentally different from the order in living systems.
There is no sense in which we can say that Hume destroyed the intellectual coherence of design thinking. William Paley could already see this in 1802.
The research paper avers, “These results support the capability of molecular replicators to spontaneously develop complexity through Darwinian evolution.”
In recent years, MIT physicist Jeremy England has gained media attention for proposing a thermodynamic energy-dissipation model of the origin of life.
This isn’t the sort of hurdle that mindless natural processes can overcome, but it is precisely the sort of problem that a designing mind could solve.