There is one point of confusion in descriptions of this year’s prize winners. It’s the talk of “directed evolution.”
The nucleus is a beehive of activity, where information is not just stored but processed, protected, transcribed, and duplicated by highly complex machines.
Why not treat the whole genome as functional? This is a radical concept, but perhaps the focus on genes distorts our understanding.
Details of the nuclear pore complex, one of the largest and most complex protein systems in the cell, come into sharper focus as a team watches how it validates a messenger RNA.
“Male mice grow ovaries instead of testes if they are missing a small region of DNA that doesn’t contain any genes,” reports the Francis Crick Institute.