It should be obvious: if you are controlling the mutations and selecting the outcomes, you are not doing Darwinism.
Genomics has come a long way since the central dogma and junk DNA. If you expect to find reasons for things, you often do find them.
It’s an uninhabited, inhospitable place where hopes die for life by chance.
We are nearing a half-century since Eigen wrote about this paradox, and it “still challenges theoretical biologists.”