Brian Miller discusses the Levinthal paradox of the interactome, the long odds of blind processes assembling the first cell, and the challenge of cell death.
When I was in charge of the Emergency Room at Los Angeles County Hospital, I saw many instances of near-death trauma, yet there was little complaint about pain.
The problems range from the extreme improbabilities associated with protein assembly, to what precisely has gone missing in the nanosecond when a cell dies.
It takes foresight to make complex tools and procedures that can restore the functions of other tools. A blind process can only see the immediate present.
Even tissues have to deal with the dead, and like everything else they do, they excel at it. The number of players involved in cell death is truly astonishing.