Extremely improbable events must be macroscopically (simply) describable to be forbidden.
A helpful formulation comes from podcaster Scott Adams, of “Dilbert” fame, who comments entertainingly on the political scene.
I also have a scheme that I believe can defeat the generalized second law. My scheme is called “intelligence.”
You do not need to study mutations for thirty years to predict that bombarding plant chromosomes with radiation will not lead to major agricultural advances.
Reproduction is the most fundamental characteristic of life. We see it happen everywhere, so we may feel there is nothing “unnatural” about it.