In effect, protein engineers are using the power of random change plus intelligent design to see what if anything will improve function.
There is one point of confusion in descriptions of this year’s prize winners. It’s the talk of “directed evolution.”
The problem these efforts face in the lab is exactly the problem faced by Darwin’s evolutionary mechanism in the wild.
Details of the nuclear pore complex, one of the largest and most complex protein systems in the cell, come into sharper focus as a team watches how it validates a messenger RNA.
He might not welcome my saying so, but his emphasis on thinking critically and examining evidence is spot-on.