Doolittle predicts, from an evolutionary framework, that jawless vertebrates would have a simpler blood clotting cascade than the human system.
The coagulation cascade cannot evolve unless there is simultaneously a mechanism in hand for controlling it. Both would have to arise at the same time.
Recently, a commenter on the Center for Science and Culture’s Facebook page asked about a paper by the late biochemist Russell F. Doolittle.
Let me tell a little story about blood clotting, Russell Doolittle, and Michael Ruse.