Without foresight to solve heterochiral incidents, a primordial cell would quickly perish even if, against all odds, it began homochiral.
Replication or transcription of DNA stresses the macromolecule, resulting in supercoiling. Topoisomerase II relieves the stress.
Science provides a clear expectation of what natural processes produce, and what we observe in the biopolymers of life is dramatically unexpected.
Brian Miller discusses the Levinthal paradox of the interactome, the long odds of blind processes assembling the first cell, and the challenge of cell death.
Any progress toward life would be lost if a fully functional cell did not emerge within a reasonably short period of time.