There are sound counterarguments to the plethora of schemes that OOL researchers devise in trying to account for how life could have emerged abiotically.
Abiogenesis is the prebiotic process wherein life, such as a cell, arises from non-living materials such as simple organic compounds.
Without foresight to solve heterochiral incidents, a primordial cell would quickly perish even if, against all odds, it began homochiral.
Replication or transcription of DNA stresses the macromolecule, resulting in supercoiling. Topoisomerase II relieves the stress.
Science provides a clear expectation of what natural processes produce, and what we observe in the biopolymers of life is dramatically unexpected.