“Warm little ponds,” in Darwin’s quaint expression, are actually very hostile environments for generating nucleotides.
A common attempt to overcome the need for information in the first cell is to equate information to a reduction in entropy.
A “self-cleaving ribozyme,” Pistol has to redeem itself without shooting the RNA World in the foot.
Now it seems that limits to evolution have become an argument for evolution.
Ribozyme experiments suggest that for life to originate, what was needed was a goal in mind, an agent in charge, with the means to implement a preconceived plan. We have a name for that.