Why not treat the whole genome as functional? This is a radical concept, but perhaps the focus on genes distorts our understanding.
Details of the nuclear pore complex, one of the largest and most complex protein systems in the cell, come into sharper focus as a team watches how it validates a messenger RNA.
“Male mice grow ovaries instead of testes if they are missing a small region of DNA that doesn’t contain any genes,” reports the Francis Crick Institute.
The implication of design, while no doubt unintended, is so powerful it almost doesn’t need to be spelled out.
Protein folds show more flexibility than previously thought, but the flexibility appears designed. If it’s hard to get one fold to work, how about two in the same protein?